PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques
K. D. Kauffman, S. Sakai, N. E. Lora, S. Namasivayam, P. J. Baker, O. Kamenyeva, T. W. Foreman, C. E. Nelson, D. Oliveira-de-Souza, C. L. Vinhaes, Z. Yaniv, C. S. Lindestam Arleham, A. Sette, G. J. Freeman, R. Moore, , D. L. Barber
This study shows that PD-1 blockade worsens Mycobacterium tuberculosis infection in rhesus macaques by increasing bacterial loads and altering immune responses.
bioRxiv · Aug 5, 2020Immunology