C. E. Nelson

Precision and efficacy of RNA-guided DNA integration in high-expressing muscle loci

This study evaluates CRISPR-based gene integration in skeletal muscle using two high-expressing loci, demonstrating high-level therapeutic gene expression in mouse myoblasts.

Enrichable consortia of microbial symbionts degrade macroalgal polysaccharides in Kyphosus fish

This study identifies microbial symbionts in Kyphosus fish that collaboratively degrade macroalgal polysaccharides through genomic analysis and suggests their potential for industrial applications.

Divergent recovery trajectories in reef-building corals following a decade of successive marine heatwaves

This study tracks recovery trajectories of two coral species after multiple marine heatwaves, finding divergent recovery patterns between species and within species based on bleaching resistance.

IL-10 suppresses T cell expansion while promoting tissue-resident memory cell formation during SARS-CoV-2 infection in rhesus macaques

This study examines the roles of IFNγ and IL-10 in SARS-CoV-2 infection of rhesus macaques, finding IL-10 suppresses T cell expansion but promotes tissue-resident memory cell formation.

Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine candidate is protective in macaques

This study evaluates an intranasal parainfluenza virus-vectored SARS-CoV-2 vaccine in macaques, showing it induces mucosal and systemic immunity and protects against viral challenge.

Longitudinal examination of perfusion and angiogenesis markers in primary colorectal tumors shows distinct signatures for metronomic and maximum-tolerated dose strategies

This study compares metronomic and maximum-tolerated dose chemotherapy in colorectal cancer using optical and molecular methods, showing distinct angiogenesis and metabolic signatures.

Mild SARS-CoV-2 infection in rhesus macaques is associated with viral control prior to antigen-specific T cell responses in tissues

This study shows that SARS-CoV-2 replication declines in the lungs before T cell responses, while innate immunity restricts viral replication in nasal and oral mucosa in rhesus macaques.

CD4 T cells are rapidly depleted from tuberculosis granulomas following acute SIV co-infection

This study shows that acute SIV co-infection rapidly depletes CD4 T cells from tuberculosis granulomas before systemic CD4 T cell loss or disease reactivation.

The human innate immune protein calprotectin elicits a multi-metal starvation response in Pseudomonas aeruginosa

This paper shows that calprotectin induces multi-metal starvation in Pseudomonas aeruginosa through proteomics, revealing non-additive regulatory responses and virulence-related changes.

Marine heatwaves depress metabolic activity and impair cellular acid-base homeostasis in reef-building corals regardless of bleaching susceptibility

This study shows marine heatwaves reduce metabolic activity and impair acid-base homeostasis in reef-building corals, regardless of their bleaching resistance.

PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques

This study shows that PD-1 blockade worsens Mycobacterium tuberculosis infection in rhesus macaques by increasing bacterial loads and altering immune responses.

Evidence for a biological source of widespread, reproducible nighttime oxygen spikes in tropical reef ecosystems has implications for coral health

The paper identifies nighttime oxygen spikes in tropical reef ecosystems as a biological phenomenon linked to coral health and calcifying organisms.

Proteomic analysis of the Pseudomonas aeruginosa iron starvation response reveals PrrF sRNA-dependent regulation of amino acid metabolism, iron-sulfur cluster biogenesis, motility, and zinc homeostasis

This study uses proteomics to identify iron-regulated processes in Pseudomonas aeruginosa under iron starvation, revealing PrrF sRNA-dependent regulation of amino acid metabolism, iron-sulfur cluster biogenesis, motility, and zinc homeostasis.