I. Budin

Leaflet-specific phospholipid imaging using genetically encoded proximity sensors

This paper introduces FACES, a tool for imaging lipid pools and transbilayer orientation in living cells, and applies it to study lipid transfer proteins and membrane asymmetry.

Organelle-targeted Laurdans measure heterogeneity in subcellular membranes and their responses to saturated lipid stress

This study develops organelle-targeted Laurdan probes to measure membrane packing heterogeneity and responses to saturated lipid stress in specific cellular compartments.

Intracellular sphingolipid sorting drives membrane phase separation in the yeast vacuole

The paper shows that sphingolipid sorting into the yeast vacuole membrane drives membrane phase separation and micro-lipophagy under glucose restriction.

Cristae formation is a mechanical buckling event controlled by the inner membrane lipidome

The paper shows that cardiolipin buffers mitochondrial inner membrane curvature and ATP synthase organization, with a mathematical model predicting snapthrough instability in cristae formation.

Vacuole phase-partitioning boosts mitochondria activity and cell lifespan through an inter-organelle lipid pipeline

The paper identifies a lipid trafficking pathway between yeast vacuoles and mitochondria that enhances mitochondrial activity and cell lifespan under glucose starvation.

Distinct functional roles for hopanoid composition in the chemical tolerance of Zymomonas mobilis

This study investigates the role of hopanoid composition in the chemical tolerance of Zymomonas mobilis, showing that reduced hopanoid content and modified head group composition affect ethanol tolerance, while hopanoid amount influences low pH survival.