Author

C. Tzaferis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 6 Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

G. Kollias· 5 shared A. Prados· 4 shared F. Roumelioti· 3 shared P. Chouvardas· 3 shared A. Liakos· 2 shared D. Konstantopoulos· 2 shared D. Papadopoulou· 2 shared M. Armaka· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersCell Biology

G. Kollias

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Cellular complexity and crosstalk in murine TNF-dependent ileitis: Different fibroblast subsets propel spatially defined ileal inflammation through TNFR1 signalling

L. Iliopoulou, C. Tzaferis, A. Prados, F. Roumelioti, V. Koliaraki, G. Kollias

This study identifies fibroblast subsets in murine TNF-dependent ileitis that drive inflammation through TNFR1 signaling in distinct intestinal layers.

bioRxiv · Sep 29, 2023 · PreprintCell Biology

Repurposing of Amisulpride, a known antipsychotic drug, to target synovial fibroblasts activation in arthritis.

D. Papadopoulou, F. Roumelioti, C. Tzaferis, P. Chouvardas, A.-K. Pedersen, F. Charalampous, E. Christodoulou-Vafeiadou, L. Ntari, N. Karagianni, M. Denis, J. V. Olsen, A. N. Matralis, G. Kollias

This study identifies Amisulpride as a potential therapeutic for arthritis by reducing synovial fibroblast activation, independent of its known targets.

bioRxiv · Aug 2, 2022 · PreprintPharmacology & Toxicology

Single-cell chromatin and transcriptome dynamics of Synovial Fibroblasts transitioning from homeostasis to pathology in modelled TNF-driven arthritis

M. Armaka, D. Konstantopoulos, C. Tzaferis, M. D. Lavigne, M. Sakkou, A. Liakos, P. P. Sfikakis, M. A. Dimopoulos, M. Fousteri, G. Kollias

This study profiles single-cell transcriptomes and chromatin accessibility of synovial fibroblasts in TNF-driven arthritis, identifying disease-specific subtypes and key regulatory factors.

Genome Medicine · Jul 26, 2022Peer-reviewedCell Biology

miR-221/222 drive synovial fibroblast expansion and pathogenesis of TNF-mediated arthritis

F. Roumelioti, C. Tzaferis, D. Konstantopoulos, D. Papadopoulou, A. Prados, M. Sakkou, A. Liakos, P. Chouvardas, T. Meletakos, Y. Pandis, N. Karagianni, M. Denis, M. Fousteri, M. Armaka, G. Kollias

This study shows miR-221/222 promotes synovial fibroblast expansion and worsens TNF-mediated arthritis by regulating cell cycle and ECM pathways.

bioRxiv · Jul 22, 2022 · PreprintCell Biology

Col6a1+/CD201+ mesenchymal cells regulate intestinal morphogenesis and homeostasis

M.-T. Melissari, A. Henriques, C. Tzaferis, A. Prados, M. E. Sarris, P. Chouvardas, S. Grammenoudi, G. Kollias, V. Koliaraki

The paper identifies and characterizes Col6a1+/CD201+ mesenchymal cells in the intestine, showing their role in morphogenesis, homeostasis, and plasticity during inflammation.

bioRxiv · Feb 16, 2021Cell Biology

Tumor MHCII immunity requires in situ antigen presentation by cancer-associated fibroblasts.

D. Kerdidani, E. Aerakis, K.-M. Verrou, P. Stamoulis, K. Goudevenou, A. Prados, C. Tzaferis, I. Vamvakaris, E. Kaniaris, K. Vachlas, E. Sepsas, K. Potaris, A. Koutsopoulos, M. Tsoumakidou

This study shows that cancer-associated fibroblasts present antigens in situ to activate CD4 T cells, enhancing tumor immunity and suggesting new therapeutic strategies.

bioRxiv · Mar 24, 2020Immunology