Repurposing of Amisulpride, a known antipsychotic drug, to target synovial fibroblasts activation in arthritis.
D. Papadopoulou, F. Roumelioti, C. Tzaferis, P. Chouvardas, A.-K. Pedersen, F. Charalampous, E. Christodoulou-Vafeiadou, L. Ntari, N. Karagianni, M. Denis, J. V. Olsen, A. N. Matralis, G. Kollias
This study identifies Amisulpride as a potential therapeutic for arthritis by reducing synovial fibroblast activation, independent of its known targets.
bioRxiv · Aug 2, 2022 · PreprintPharmacology & Toxicology