Author

M. Denis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Evolutionary Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

C. Tzaferis· 2 shared D. Papadopoulou· 2 shared F. Roumelioti· 2 shared G. Kollias· 2 shared N. Karagianni· 2 shared P. Chouvardas· 2 shared A. D. Czechowicz· 1 shared A. Girsen· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersPharmacology & Toxicology

C. Tzaferis

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

In Utero Hematopoietic Stem Cell Transplant for Fanconi Anemia

L. Swartzrock, C. Dib, M. Denis, H. Willner, K. Ho, E. Haslett, M. R. Krampf, A. Girsen, Y. J. Blumenfeld, Y. Y. El-Sayed, M. G. Roncarolo, T. C. MacKenzie, A. D. Czechowicz

This study demonstrates that in utero hematopoietic stem cell transplantation (HSCT) without conditioning can effectively engraft donor cells in FA mouse models, achieving high donor chimerism and potentially offering a safe prenatal treatment for FA.

bioRxiv · May 9, 2024 · PreprintCell Biology

Repurposing of Amisulpride, a known antipsychotic drug, to target synovial fibroblasts activation in arthritis.

D. Papadopoulou, F. Roumelioti, C. Tzaferis, P. Chouvardas, A.-K. Pedersen, F. Charalampous, E. Christodoulou-Vafeiadou, L. Ntari, N. Karagianni, M. Denis, J. V. Olsen, A. N. Matralis, G. Kollias

This study identifies Amisulpride as a potential therapeutic for arthritis by reducing synovial fibroblast activation, independent of its known targets.

bioRxiv · Aug 2, 2022 · PreprintPharmacology & Toxicology

miR-221/222 drive synovial fibroblast expansion and pathogenesis of TNF-mediated arthritis

F. Roumelioti, C. Tzaferis, D. Konstantopoulos, D. Papadopoulou, A. Prados, M. Sakkou, A. Liakos, P. Chouvardas, T. Meletakos, Y. Pandis, N. Karagianni, M. Denis, M. Fousteri, M. Armaka, G. Kollias

This study shows miR-221/222 promotes synovial fibroblast expansion and worsens TNF-mediated arthritis by regulating cell cycle and ECM pathways.

bioRxiv · Jul 22, 2022 · PreprintCell Biology

Gene expression variability across cells and species shapes innate immunity

T. Hagai, X. Chen, R. J. Miragaia, T. Gomes, R. Rostom, N. Kunowska, V. Proserpio, G. Donati, L. Bossini-Castillo, G. Naamati, G. Emerton, G. Trynka, I. Kondova, M. Denis, S. A. Teichmann

The paper examines how gene expression variability across cells and species influences innate immune responses, finding that rapidly diverging genes show high variability while regulatory genes are conserved.

bioRxiv · Sep 24, 2017Evolutionary Biology