C.-C. Chu

A quantitative model predicts how m6A reshapes the kinetic landscape of nucleic acid hybridization and conformational transitions

The paper shows m6A modification slows nucleic acid hybridization by altering conformational dynamics through isomerization pathways.

Revealing the high propensity of RNAs to non-specifically bind drug-like small molecules

This study examines the non-specific binding of three drug-like compounds to HIV-1 stem-loop RNAs, showing they inhibit RNA function and exhibit off-target interactions.

Rice NIN-LIKE PROTEIN 4 is a master regulator of nitrogen use efficiency

This study identifies OsNLP4 as a master regulator of nitrogen use efficiency in rice, showing it improves yield and NUE through transcriptional regulation of nitrogen-related genes.

m6A minimally impacts the structure, dynamics, and Rev ARM binding properties of HIV-1 RRE stem IIB

This study shows that m6A modification in HIV-1 RRE stem IIB has minimal effects on structure, dynamics, and Rev ARM binding.

Probing RNA conformational equilibria within the functional cellular context

The paper develops a method to assess RNA excited-state stability and abundance in cells using mutations and applies it to HIV-1 regulatory RNAs, showing ESs form with comparable abundance in vitro and in vivo.

Dynamic ensemble of HIV-1 RRE stem IIB reveals non-native conformations that disrupt the Rev binding site

The paper identifies non-native conformations in HIV-1 RRE stem IIB that disrupt Rev binding and are potential targets for anti-HIV therapeutics.