Author

C.-D. Pham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Assay:metabolomics· 2 Organism:human· 1 Organism:non-human primate· 1 Organism:rat· 1 Approach:statistical model· 1

Frequent Co-Authors

F. L. Muller· 4 shared V. C. Yan· 4 shared K. Arthur· 2 shared S. Khadka· 2 shared S. W. Millward· 2 shared A. J. Yan· 1 shared A. Jebet· 1 shared B. N. Dominy· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersPharmacology & Toxicology

F. L. Muller

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Enolase inhibitors as therapeutic leads for Naegleria fowleri infection

J. E. Milanes, V. C. Yan, C.-D. Pham, F. L. Muller, S. Kwain, K. C. Rees, B. N. Dominy, D. C. Whitehead, S. W. Millward, M. Bolejack, J. Abendroth, I. Q. Phan, B. Staker, E. A. Moseman, X. Zhang, , J. Morris

This paper shows that enolase inhibitors, specifically HEX, are effective against Naegleria fowleri by inhibiting its glycolytic pathway and extending survival in infected rodents.

bioRxiv · Jan 16, 2024 · PreprintBiochemistry

Quantification of phosphonate drugs by 1H-31P HSQC shows that rats are better models of primate drug exposure than mice

Y. Barekatain, S. Khadka, K. Harris, J. Delacerda, V. C. Yan, K.-C. Chen, C.-D. Pham, M. N. Uddin, R. Avritcher, E. J. Eisenberg, R. Kalluri, S. W. Millward, F. L. Muller

The paper quantifies phosphonate drugs using 1H-31P HSQC NMR, showing rats provide better drug exposure models than mice for phosphonate-containing compounds.

bioRxiv · Jan 30, 2022Pharmacology & Toxicology

Pharmacokinetics of Orally Administered GS-441524 in Dogs

V. C. Yan, C.-D. Pham, M. J. Yan, A. J. Yan, S. Khadka, K. Arthur, J. J. Ackroyd, D. K. Georgiou, L. E. Roon, L. R. Bushman, P. L. Anderson, C. Li, F. L. Muller

This study evaluates the oral bioavailability of GS-441524 in dogs, showing sustained plasma concentrations above the EC50 for SARS-CoV-2.

bioRxiv · Feb 4, 2021 · PreprintPharmacology & Toxicology

Aliphatic Amines are Viable Pro-drug Moieties in Phosphonoamidate Drugs

V. C. Yan, C.-D. Pham, K. Arthur, F. L. Muller

This study demonstrates that small aliphatic amines are more effective than L-alanine or benzylamine as pro-drug moieties for phosphonate inhibitors, expanding the range of possible pro-drug leave groups.

bioRxiv · Apr 5, 2020Cancer Biology