Author

D. C. Whitehead

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

B. N. Dominy· 2 shared K. C. Rees· 2 shared K. Floyd· 2 shared M. Key· 2 shared S. Kwain· 2 shared Z. Dou· 2 shared A. Alexander-Bryant· 1 shared A. Bergmann· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

B. N. Dominy

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Enolase inhibitors as therapeutic leads for Naegleria fowleri infection

J. E. Milanes, V. C. Yan, C.-D. Pham, F. L. Muller, S. Kwain, K. C. Rees, B. N. Dominy, D. C. Whitehead, S. W. Millward, M. Bolejack, J. Abendroth, I. Q. Phan, B. Staker, E. A. Moseman, X. Zhang, , J. Morris

This paper shows that enolase inhibitors, specifically HEX, are effective against Naegleria fowleri by inhibiting its glycolytic pathway and extending survival in infected rodents.

bioRxiv · Jan 16, 2024 · PreprintBiochemistry

Enhancing Drug Delivery with Supramolecular Amphiphilic Macrocycle Nanoparticles: Selective Targeting of CDK4/6 Inhibitor Palbociclib to Melanoma

M. F. Attia, E. A. Ogunnaike, M. Pitz, N. M. Elbaz, D. K. Panda, A. Alexander-Bryant, S. Saha, D. C. Whitehead, A. Kabanov

This paper develops amphiphilic macrocycle nanoparticles for targeted drug delivery of Palbociclib to melanoma cells, showing selective targeting and minimal toxicity.

bioRxiv · Nov 21, 2023Pharmacology & Toxicology

A cathepsin C-like protease post-translationally modifies Toxoplasma gondii secretory proteins for optimal invasion and egress.

L. B. Thornton, M. Key, C. Micchelli, A. J. Stasic, S. Kwain, K. Floyd, S. N. J. Moreno, B. N. Dominy, D. C. Whitehead, Z. Dou

This study identifies TgCPC1, a cathepsin C-like protease in Toxoplasma gondii, as essential for the post-translational modification of micronemal proteins required for invasion and egress.

bioRxiv · Jan 21, 2023 · PreprintMicrobiology

Toxoplasma gondii requires its plant-like heme biosynthesis pathway for infection.

A. Bergmann, K. Floyd, M. Key, C. Dameron, K. C. Rees, D. C. Whitehead, I. Hamza, Z. Dou

This study shows Toxoplasma gondii relies on its plant-like heme biosynthesis pathway for infection and demonstrates oxadiazon and its derivatives inhibit growth, suggesting heme biosynthesis as a therapeutic target.

PLOS Pathogens · May 14, 2020Peer-reviewedMicrobiology