Author

K. Arthur

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 3 Assay:metabolomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:differential expression· 1 Research Focus:dimensionality reduction· 1

Frequent Co-Authors

F. L. Muller· 5 shared V. C. Yan· 5 shared J. J. Ackroyd· 4 shared D. K. Georgiou· 3 shared S. Khadka· 3 shared Y. Barekatain· 3 shared C.-D. Pham· 2 shared J. De Groot· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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5 shared papersCancer Biology

F. L. Muller

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5 papers

Recent·Most cited

Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism

S. Khadka, Y.-H. Lin, J. J. Ackroyd, Y.-A. Chen, Y. Sheng, W. Qian, S. Guo, Y. Chen, E. I. Behr, Y. Barekatain, M. N. Uddin, K. Arthur, V. C. Yan, E. Chang, A. Poral, , F. L. Muller

This study shows that angiogenesis inhibitors enhance the effectiveness of metabolic therapies in gliomas by inducing anaplerotic nutrient stress.

bioRxiv · May 7, 2023 · PreprintCancer Biology

Pharmacokinetics of Orally Administered GS-441524 in Dogs

V. C. Yan, C.-D. Pham, M. J. Yan, A. J. Yan, S. Khadka, K. Arthur, J. J. Ackroyd, D. K. Georgiou, L. E. Roon, L. R. Bushman, P. L. Anderson, C. Li, F. L. Muller

This study evaluates the oral bioavailability of GS-441524 in dogs, showing sustained plasma concentrations above the EC50 for SARS-CoV-2.

bioRxiv · Feb 4, 2021 · PreprintPharmacology & Toxicology

Aliphatic Amines are Viable Pro-drug Moieties in Phosphonoamidate Drugs

V. C. Yan, C.-D. Pham, K. Arthur, F. L. Muller

This study demonstrates that small aliphatic amines are more effective than L-alanine or benzylamine as pro-drug moieties for phosphonate inhibitors, expanding the range of possible pro-drug leave groups.

bioRxiv · Apr 5, 2020Cancer Biology

Robust detection of oncometabolic aberrations by 1H-13C heteronuclear single quantum correlation in live cells and intact tumors ex-vivo

Y. Barekatain, V. C. Yan, K. Arthur, J. J. Ackroyd, S. Khadka, J. De Groot, J. T. Huse, F. L. Muller

This paper demonstrates that 1H-13C HSQC NMR can detect oncometabolic aberrations in live cells and tumors without specialized equipment, improving sensitivity and resolution over traditional methods.

bioRxiv · Dec 18, 2019Biophysics

Methylthioadenosine is Not Dramatically Elevated in MTAP-Homozygous Deleted Primary Glioblastomas

Y. Barekatain, V. C. Yan, J. J. Ackroyd, A. H. Poral, T. Tran, D. K. Georgiou, K. Arthur, A. deCarvalho, Y.-H. Lin, N. B. Satani, E. S. Ballato, R. Verhaak, J. de Groot, J. T. Huse, J. M. Asara, F. L. Muller

This paper shows that MTA levels are not significantly elevated in MTAP-homozygous deleted primary human glioblastomas, challenging the clinical relevance of targeting PRMT5 and MAT2A in these tumors.

bioRxiv · Oct 18, 2019Cancer Biology

K. Arthur · henhao