Author

I. Q. Phan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:metabolomics· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

J. Abendroth· 2 shared J. E. Milanes· 2 shared A. Jebet· 1 shared B. N. Dominy· 1 shared B. Staker· 1 shared C.-D. Pham· 1 shared D. C. Whitehead· 1 shared D. M. Dranow· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

J. Abendroth

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Enolase inhibitors as therapeutic leads for Naegleria fowleri infection

J. E. Milanes, V. C. Yan, C.-D. Pham, F. L. Muller, S. Kwain, K. C. Rees, B. N. Dominy, D. C. Whitehead, S. W. Millward, M. Bolejack, J. Abendroth, I. Q. Phan, B. Staker, E. A. Moseman, X. Zhang, , J. Morris

This paper shows that enolase inhibitors, specifically HEX, are effective against Naegleria fowleri by inhibiting its glycolytic pathway and extending survival in infected rodents.

bioRxiv · Jan 16, 2024 · PreprintBiochemistry

A divergent protein kinase A in the human pathogen Leishmania is associated with cell cortex microtubules and controls cell shape

R. Fischer-Weinberger, S. Bachmaier, V. Ober, G. B. Githure, R. Dandugudumuoa, I. Q. Phan, M. Almoznino, E. Polatoglou, P. Tsigankove, R. Nitzan Koren, P. J. Myler, M. J. Boshart, D. Zilberstein

This paper identifies a novel PKA regulatory subunit in Leishmania that localizes to microtubules and controls promastigote shape by tethering the catalytic subunit to the cell cortex.

bioRxiv · Apr 24, 2021 · PreprintCell Biology

A doublecortin-domain protein of Toxoplasma and its orthologues bind to and modify the structure and organization of tubulin polymers

J. M. Leung, E. Nagayasu, Y.-C. Hwang, J. Liu, P. Pierce, I. Q. Phan, R. A. Prentice, J. M. Murray, K. Hu

This study identifies TgDCX, a Toxoplasma protein that binds and modifies tubulin polymers, enabling curved structures critical for parasite invasion.

bioRxiv · Jan 15, 2020Cell Biology

Enzymatic and structural characterization of the Naegleria fowleri glucokinase

J. E. Milanes, J. Suryadi, J. Abendroth, W. C. Van Voorhis, K. F. Barrett, D. M. Dranow, I. Q. Phan, S. L. Patrick, S. D. Rozema, M. M. Khalifa, J. E. Golden, J. C. Morris

This study characterizes the enzymatic properties and structure of Naegleria fowleri glucokinase, identifying potential inhibitors for therapeutic development against the parasite.

bioRxiv · Nov 14, 2018Biochemistry