Author

D. K. Georgiou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:metabolomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

F. L. Muller· 3 shared J. J. Ackroyd· 3 shared K. Arthur· 3 shared V. C. Yan· 3 shared J. M. Asara· 2 shared S. Khadka· 2 shared T. Tran· 2 shared Y. Barekatain· 2 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersCancer Biology

F. L. Muller

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3 papers

Recent·Most cited

Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism

S. Khadka, Y.-H. Lin, J. J. Ackroyd, Y.-A. Chen, Y. Sheng, W. Qian, S. Guo, Y. Chen, E. I. Behr, Y. Barekatain, M. N. Uddin, K. Arthur, V. C. Yan, E. Chang, A. Poral, , F. L. Muller

This study shows that angiogenesis inhibitors enhance the effectiveness of metabolic therapies in gliomas by inducing anaplerotic nutrient stress.

bioRxiv · May 7, 2023 · PreprintCancer Biology

Pharmacokinetics of Orally Administered GS-441524 in Dogs

V. C. Yan, C.-D. Pham, M. J. Yan, A. J. Yan, S. Khadka, K. Arthur, J. J. Ackroyd, D. K. Georgiou, L. E. Roon, L. R. Bushman, P. L. Anderson, C. Li, F. L. Muller

This study evaluates the oral bioavailability of GS-441524 in dogs, showing sustained plasma concentrations above the EC50 for SARS-CoV-2.

bioRxiv · Feb 4, 2021 · PreprintPharmacology & Toxicology

Methylthioadenosine is Not Dramatically Elevated in MTAP-Homozygous Deleted Primary Glioblastomas

Y. Barekatain, V. C. Yan, J. J. Ackroyd, A. H. Poral, T. Tran, D. K. Georgiou, K. Arthur, A. deCarvalho, Y.-H. Lin, N. B. Satani, E. S. Ballato, R. Verhaak, J. de Groot, J. T. Huse, J. M. Asara, F. L. Muller

This paper shows that MTA levels are not significantly elevated in MTAP-homozygous deleted primary human glioblastomas, challenging the clinical relevance of targeting PRMT5 and MAT2A in these tumors.

bioRxiv · Oct 18, 2019Cancer Biology