F. L. Muller

Enolase inhibitors as therapeutic leads for Naegleria fowleri infection

This paper shows that enolase inhibitors, specifically HEX, are effective against Naegleria fowleri by inhibiting its glycolytic pathway and extending survival in infected rodents.

Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism

This study shows that angiogenesis inhibitors enhance the effectiveness of metabolic therapies in gliomas by inducing anaplerotic nutrient stress.

NAD+ biosynthesis as a collateral lethality target for precision oncology

The paper identifies NMNAT2 as a collateral lethality target in cancers with NMNAT1 deletions, showing selective toxicity in vitro and tumor eradication in vivo.

Genetic depletion of de novo coenzyme A biosynthesis exacerbates puromycin toxicity

The paper shows that reducing coenzyme A biosynthesis increases cancer cells' sensitivity to puromycin, a selection antibiotic used in research.

Generation and validation of an anti-human PANK3 mouse monoclonal antibody

The paper generates and validates a mouse monoclonal antibody against human PANK3 to enable reliable detection of this enzyme in cancer cell lines.

Quantification of phosphonate drugs by 1H-31P HSQC shows that rats are better models of primate drug exposure than mice

The paper quantifies phosphonate drugs using 1H-31P HSQC NMR, showing rats provide better drug exposure models than mice for phosphonate-containing compounds.

Protein-Metabolite Interactomics Reveals Novel Regulation of Carbohydrate Metabolism

The paper develops the MIDAS platform to identify protein-metabolite interactions, revealing novel regulatory mechanisms in carbohydrate metabolism.

Pharmacokinetics of Orally Administered GS-441524 in Dogs

This study evaluates the oral bioavailability of GS-441524 in dogs, showing sustained plasma concentrations above the EC50 for SARS-CoV-2.

Structure-guided microbial targeting of antistaphylococcal prodrugs

This study identifies microbial esterases in Staphylococcus aureus and determines their substrate specificities to guide the design of serum esterase-resistant antistaphylococcal prodrugs.

Targeting host glycolysis as a strategy for antimalarial development.

The paper investigates enolase inhibitors' effects on erythrocytes and their implications for antimalarial therapy by examining red blood cell homeostasis and parasite growth.

Aliphatic Amines are Viable Pro-drug Moieties in Phosphonoamidate Drugs

This study demonstrates that small aliphatic amines are more effective than L-alanine or benzylamine as pro-drug moieties for phosphonate inhibitors, expanding the range of possible pro-drug leave groups.

Robust detection of oncometabolic aberrations by 1H-13C heteronuclear single quantum correlation in live cells and intact tumors ex-vivo

This paper demonstrates that 1H-13C HSQC NMR can detect oncometabolic aberrations in live cells and tumors without specialized equipment, improving sensitivity and resolution over traditional methods.

Methylthioadenosine is Not Dramatically Elevated in MTAP-Homozygous Deleted Primary Glioblastomas

This paper shows that MTA levels are not significantly elevated in MTAP-homozygous deleted primary human glioblastomas, challenging the clinical relevance of targeting PRMT5 and MAT2A in these tumors.