A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication and pathogenesis in vivo
T. Y. Taha, R. K. Suryawanshi, I. P. Chen, G. J. Correy, P. C. O'Leary, M. P. Jogalekar, M. McCavitt-Malvido, M. Diolaiti, G. R. Kimmerly, C.-L. Tsou, L. Martinez-Sobrido, N. J. Krogan, A. Ashworth, J. S. Fraser, M. Ott
This study shows that mutating the SARS-CoV-2 NSP3 Mac1 domain reduces viral replication and pathogenesis in vivo.
bioRxiv · Apr 18, 2023 · PreprintMicrobiology