Author

M. McCavitt-Malvido

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:metagenomics· 1 Organism:non-human primate· 1 Assay:proteomics· 1

Frequent Co-Authors

M. Ott· 3 shared G. R. Kumar· 2 shared I. P. Chen· 2 shared N. J. Krogan· 2 shared R. Suryawanshi· 2 shared T. Y. Taha· 2 shared A. Ashworth· 1 shared A. Ciling· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersMicrobiology

M. Ott

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Author profile →

4 papers

Recent·Most cited

Regulation of virion production by the ORF8 signal peptide across SARS-CoV-2 variants

M. M. Khalid, I. Chen, F. S. Soveg, T. Y. Taha, T. Tabata, R. Suryawanshi, A. M. Syed, A. Ciling, M. McCavitt-Malvido, U. Schulze-Gahmen, J. Hayashi, I.-J. Kim, S. W. Fong, J. Batra, G. R. Kumar, , M. Ott

This study shows ORF8 suppresses viral particle production by interacting with Spike and causing Golgi fragmentation, supporting evolutionary pressure to delete ORF8 in SARS-CoV-2 variants.

bioRxiv · Mar 5, 2024 · PreprintMicrobiology

Mild SARS-CoV-2 infection results in long-lasting microbiota instability

V. Upadhyay, R. Suryawanshi, P. Tasoff, M. McCavitt-Malvido, G. R. Kumar, V. Murray, C. Noecker, J. E. Bisanz, Y. Hswen, C. Ha, B. Sreekumar, I. P. Chen, S. V. Lynch, M. Ott, S. Lee, P. J. Turnbaugh

This study shows that mild SARS-CoV-2 infection causes long-term gut microbiota instability in both humans and mice, with Omicron variant also disrupting microbial communities despite causing milder symptoms.

mBio · Jun 9, 2023Peer-reviewedMicrobiology

A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication and pathogenesis in vivo

T. Y. Taha, R. K. Suryawanshi, I. P. Chen, G. J. Correy, P. C. O'Leary, M. P. Jogalekar, M. McCavitt-Malvido, M. Diolaiti, G. R. Kimmerly, C.-L. Tsou, L. Martinez-Sobrido, N. J. Krogan, A. Ashworth, J. S. Fraser, M. Ott

This study shows that mutating the SARS-CoV-2 NSP3 Mac1 domain reduces viral replication and pathogenesis in vivo.

bioRxiv · Apr 18, 2023 · PreprintMicrobiology

Reversion of Ebolavirus Disease from a Single Intramuscular Injection of a pan-Ebolavirus Immunotherapeutic

E. Kuang, R. W. Cross, M. McCavitt-Malvido, D. M. Abelson, V. Borisevich, K. N. Agans, N. Mlakar, A. Marimuthu, D. J. Deer, W. S. Shestowsky, D. Kim, J. B. Geisbert, L. Zeitlin, C. L. Moyer, C. J. Roy, , Z. A. Bornholdt

This study shows that a single intramuscular dose of MBP431, a modified ebolavirus therapeutic, can reverse disease and provide protection in non-human primates.

bioRxiv · Jan 6, 2022Microbiology