Author

J. M. Hayashi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

M. Ott· 5 shared I. P. Chen· 3 shared M. M. Khalid· 3 shared T. Y. Taha· 3 shared A. M. Syed· 2 shared C. R. Simoneau· 2 shared J. A. Doudna· 2 shared K. Walcott· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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5 shared papersMicrobiology

M. Ott

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Author profile →

5 papers

Recent·Most cited

Rapid assembly of SARS-CoV-2 genomes reveals attenuation of the Omicron BA.1 variant through NSP6

T. Y. Taha, I. P. Chen, J. M. Hayashi, T. Tabata, K. Walcott, G. R. Kimmerly, A. M. Syed, A. Ciling, R. K. Suryawanshi, H. S. Martin, B. H. Bach, C.-L. Tsou, M. Montano, M. M. Khalid, B. K. Sreekumar, , M. Ott

The paper introduces a plasmid-based method to assemble SARS-CoV-2 genomes and identifies NSP6 mutations as causing Omicron attenuation.

bioRxiv · Jan 31, 2023 · PreprintMicrobiology

NF-κB inhibitor alpha has a cross-variant role during SARS-CoV-2 infection in ACE2-overexpressing human airway organoids

C. R. Simoneau, P.-Y. Chen, G. X. Xing, M. M. Khalid, N. L. Meyers, J. M. Hayashi, T. Y. Taha, K. E. Leon, T. Ashuach, K. A. Fontaine, L. Rodriguez, B. Joehnk, K. Walcott, S. Vasudevan, X. Fang, , M. Ott

The paper uses ACE2-overexpressing airway organoids to show NF-κB inhibitor alpha is upregulated during SARS-CoV-2 infection and its reduced function increases viral infection.

bioRxiv · Aug 2, 2022 · PreprintMicrobiology

SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein

M. Walter, I. P. Chen, A. Vallejo-Gracia, I.-J. Kim, O. Bielska, V. L. Lam, J. M. Hayashi, A. Cruz, S. Shah, J. D. Gross, N. J. Krogan, B. Schilling, M. Ott, E. Verdin

This study identifies SIRT5 as a proviral factor that interacts with SARS-CoV-2 Nsp14, enhancing viral replication and suggesting it as a therapeutic target.

bioRxiv · Jan 4, 2022Microbiology

Rapid assessment of SARS-CoV-2 evolved variants using virus-like particles

A. M. Syed, T. Y. Taha, M. M. Khalid, T. Tabata, I. P. Chen, B. Sreekumar, P.-Y. Chen, J. M. Hayashi, K. M. Soczek, M. Ott, J. A. Doudna

This study uses SARS-CoV-2 virus-like particles to rapidly assess mutations in viral variants, finding that N protein mutations enhance RNA packaging and viral spread.

bioRxiv · Aug 5, 2021Microbiology

Functional genomic screens identify human host factors for SARS-CoV-2 and common cold coronaviruses

R. Wang, C. R. Simoneau, J. Kulsuptrakul, M. Bouhaddou, K. Travisano, J. M. Hayashi, J. Carlson-Stevermer, J. Oki, K. Holden, N. J. Krogan, M. Ott, A. S. Puschnik

The paper identifies host factors and pathways common to SARS-CoV-2 and common cold coronaviruses using CRISPR screens, revealing shared and unique factors that support viral infection.

bioRxiv · Sep 24, 2020Microbiology