I. P. Chen

Mild SARS-CoV-2 infection results in long-lasting microbiota instability

This study shows that mild SARS-CoV-2 infection causes long-term gut microbiota instability in both humans and mice, with Omicron variant also disrupting microbial communities despite causing milder symptoms.

Post-acute immunological and behavioral sequelae in mice after Omicron infection

This study investigates post-acute immunological and behavioral effects in mice after Omicron infection, showing vaccination reduces pulmonary immune perturbations and behavioral deficits.

A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication and pathogenesis in vivo

This study shows that mutating the SARS-CoV-2 NSP3 Mac1 domain reduces viral replication and pathogenesis in vivo.

Rapid assembly of SARS-CoV-2 genomes reveals attenuation of the Omicron BA.1 variant through NSP6

The paper introduces a plasmid-based method to assemble SARS-CoV-2 genomes and identifies NSP6 mutations as causing Omicron attenuation.

SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein

This study identifies SIRT5 as a proviral factor that interacts with SARS-CoV-2 Nsp14, enhancing viral replication and suggesting it as a therapeutic target.

Rapid assessment of SARS-CoV-2 evolved variants using virus-like particles

This study uses SARS-CoV-2 virus-like particles to rapidly assess mutations in viral variants, finding that N protein mutations enhance RNA packaging and viral spread.

FOXO1 promotes HIV Latency by suppressing ER stress in T cells

This study shows FOXO1 promotes HIV latency by suppressing ER stress in T cells and identifies pathways to selectively reverse quiescence and reduce viral reservoirs.