Author

A. M. Syed

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 4 Organism:virus· 3 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Ciling· 4 shared J. A. Doudna· 4 shared M. M. Khalid· 4 shared M. Ott· 4 shared T. Tabata· 3 shared T. Y. Taha· 3 shared G. R. Kumar· 2 shared I. P. Chen· 2 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersMicrobiology

A. Ciling

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Regulation of virion production by the ORF8 signal peptide across SARS-CoV-2 variants

M. M. Khalid, I. Chen, F. S. Soveg, T. Y. Taha, T. Tabata, R. Suryawanshi, A. M. Syed, A. Ciling, M. McCavitt-Malvido, U. Schulze-Gahmen, J. Hayashi, I.-J. Kim, S. W. Fong, J. Batra, G. R. Kumar, , M. Ott

This study shows ORF8 suppresses viral particle production by interacting with Spike and causing Golgi fragmentation, supporting evolutionary pressure to delete ORF8 in SARS-CoV-2 variants.

bioRxiv · Mar 5, 2024 · PreprintMicrobiology

Assembly reactions of SARS-CoV-2 nucleocapsid protein with nucleic acid

H. Zhao, A. M. Syed, M. M. Khalid, A. Nguyen, A. Ciling, D. Wu, W.-M. Yau, S. Srinivasan, D. Esposito, J. A. Doudna, G. Piszczek, M. Ott, P. Schuck

This study investigates the assembly of SARS-CoV-2 nucleocapsid protein with nucleic acids using biophysical techniques and mutant proteins, revealing key interaction motifs and stabilization mechanisms.

bioRxiv · Nov 22, 2023 · PreprintBiophysics

Assembly of SARS-CoV-2 ribonucleosomes by truncated N* variant of the nucleocapsid protein

A. Adly, M. Bi, C. Carlson, A. M. Syed, A. Ciling, J. Doudna, Y. Cheng, D. O. Morgan

This study shows that the truncated N* variant of SARS-CoV-2 nucleocapsid protein can assemble into vRNPs similar to full-length N, requiring the leucine-rich helix and inhibited by a phosphomimetic SR region.

bioRxiv · Aug 16, 2023Microbiology

Rapid assembly of SARS-CoV-2 genomes reveals attenuation of the Omicron BA.1 variant through NSP6

T. Y. Taha, I. P. Chen, J. M. Hayashi, T. Tabata, K. Walcott, G. R. Kimmerly, A. M. Syed, A. Ciling, R. K. Suryawanshi, H. S. Martin, B. H. Bach, C.-L. Tsou, M. Montano, M. M. Khalid, B. K. Sreekumar, , M. Ott

The paper introduces a plasmid-based method to assemble SARS-CoV-2 genomes and identifies NSP6 mutations as causing Omicron attenuation.

bioRxiv · Jan 31, 2023 · PreprintMicrobiology

Rapid assessment of SARS-CoV-2 evolved variants using virus-like particles

A. M. Syed, T. Y. Taha, M. M. Khalid, T. Tabata, I. P. Chen, B. Sreekumar, P.-Y. Chen, J. M. Hayashi, K. M. Soczek, M. Ott, J. A. Doudna

This study uses SARS-CoV-2 virus-like particles to rapidly assess mutations in viral variants, finding that N protein mutations enhance RNA packaging and viral spread.

bioRxiv · Aug 5, 2021Microbiology