Author

T. Y. Taha

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:scRNA-seq· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

M. Ott· 5 shared M. M. Khalid· 4 shared I. P. Chen· 3 shared J. M. Hayashi· 3 shared A. M. Syed· 2 shared C. R. Simoneau· 2 shared C.-L. Tsou· 2 shared G. R. Kimmerly· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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5 shared papersMicrobiology

M. Ott

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5 papers

Recent·Most cited

A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication and pathogenesis in vivo

T. Y. Taha, R. K. Suryawanshi, I. P. Chen, G. J. Correy, P. C. O'Leary, M. P. Jogalekar, M. McCavitt-Malvido, M. Diolaiti, G. R. Kimmerly, C.-L. Tsou, L. Martinez-Sobrido, N. J. Krogan, A. Ashworth, J. S. Fraser, M. Ott

This study shows that mutating the SARS-CoV-2 NSP3 Mac1 domain reduces viral replication and pathogenesis in vivo.

bioRxiv · Apr 18, 2023 · PreprintMicrobiology

Rapid assembly of SARS-CoV-2 genomes reveals attenuation of the Omicron BA.1 variant through NSP6

T. Y. Taha, I. P. Chen, J. M. Hayashi, T. Tabata, K. Walcott, G. R. Kimmerly, A. M. Syed, A. Ciling, R. K. Suryawanshi, H. S. Martin, B. H. Bach, C.-L. Tsou, M. Montano, M. M. Khalid, B. K. Sreekumar, , M. Ott

The paper introduces a plasmid-based method to assemble SARS-CoV-2 genomes and identifies NSP6 mutations as causing Omicron attenuation.

bioRxiv · Jan 31, 2023 · PreprintMicrobiology

NF-κB inhibitor alpha has a cross-variant role during SARS-CoV-2 infection in ACE2-overexpressing human airway organoids

C. R. Simoneau, P.-Y. Chen, G. X. Xing, M. M. Khalid, N. L. Meyers, J. M. Hayashi, T. Y. Taha, K. E. Leon, T. Ashuach, K. A. Fontaine, L. Rodriguez, B. Joehnk, K. Walcott, S. Vasudevan, X. Fang, , M. Ott

The paper uses ACE2-overexpressing airway organoids to show NF-κB inhibitor alpha is upregulated during SARS-CoV-2 infection and its reduced function increases viral infection.

bioRxiv · Aug 2, 2022 · PreprintMicrobiology

Hepatitis C Virus Infects and Perturbs Liver Stem Cells

N. L. Meyers, T. Ashuach, D. E. Lyons, C. R. Simoneau, A. L. Erickson, T. T. Nguyen, M. Bouhaddou, M. M. Khalid, T. Y. Taha, V. Natarajan, J. L. Baron, N. Neff, F. Zanini, T. Mahmoudi, S. R. Quake, , M. Ott

This study identifies liver stem cells as targets of HCV infection, showing their transcriptional reprogramming and role in liver damage and cancer risk.

bioRxiv · Oct 26, 2021Microbiology

Rapid assessment of SARS-CoV-2 evolved variants using virus-like particles

A. M. Syed, T. Y. Taha, M. M. Khalid, T. Tabata, I. P. Chen, B. Sreekumar, P.-Y. Chen, J. M. Hayashi, K. M. Soczek, M. Ott, J. A. Doudna

This study uses SARS-CoV-2 virus-like particles to rapidly assess mutations in viral variants, finding that N protein mutations enhance RNA packaging and viral spread.

bioRxiv · Aug 5, 2021Microbiology