Chronic exposure to glucocorticoids amplifies inhibitory neuron cell fate during human neurodevelopment in organoids
Leander Dony, Anthi C. Krontira, Lea Kaspar, Ruhel Ahmad, Ilknur Safak Demirel, Małgorzata Grochowicz, Tim Schäfer, Fatema Begum, Vincenza Sportelli, Catarina Raimundo, Maik Ködel, Marta S. Labeur, Silvia Cappello, Fabian Joachim Theis, Cristiana Cruceanu, Elisabeth B. Binder
This study shows chronic glucocorticoid exposure alters lineage specification in human neural organoids by priming inhibitory neuron fate through transcription factors like PBX3.
Science Advances · Feb 14, 2025Peer-reviewedNeuroscience