Author

Chalini Weerasooriya

University of Toronto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:Drosophila· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:multiome· 1

Frequent Co-Authors

Craig A. SmibertiD· 2 shared Howard D. LipshitziD· 2 shared Zhuyi Wang· 2 shared Alexander J Marsolais· 1 shared Angelo KaraiskakisiD· 1 shared Harrison W. SmithiD· 1 shared Hua LuoiD· 1 shared Mariana Kekis· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersDevelopmental Biology

Craig A. SmibertORCID

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2 papers

Recent·Most cited

Pumilio and Brain tumor regulate the expression of Smaug during the Drosophila maternal-to-zygotic transition

Alexander J Marsolais, Mariana Kekis, Harrison W. Smith, Zhuyi Wang, Chalini Weerasooriya, Timothy R. Hughes, Howard D. Lipshitz, Craig A. Smibert

This study shows that Pumilio and Brain tumor regulate Smaug mRNA degradation during the Drosophila maternal-to-zygotic transition, preventing ectopic Smaug protein expression and ensuring proper mRNA clearance.

Genetics · Sep 29, 2026Peer-reviewedDevelopmental Biology

The ORB2 RNA-binding protein negatively regulates its target transcripts during the Drosophila maternal-to-zygotic transition via its functionally conserved Zinc binding 'ZZ' domain

Timothy C.H. Low, Hua Luo, Chalini Weerasooriya, Zhuyi Wang, Sichun Lin, Angelo Karaiskakis, Stéphane Angers, Craig A. Smibert, Howard D. Lipshitz

This study identifies ORB2 as a regulator of maternal mRNAs during the Drosophila MZT, showing its ZZ domain mediates repression through interactions with post-transcriptional regulators.

Genetics · Nov 6, 2025Peer-reviewedGenetics