Author

Angelo Karaiskakis

University of TorontoORCID 0000-0001-9033-2524Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:Drosophila· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell-cell communication· 1 Assay:multiome· 1

Frequent Co-Authors

Craig A. SmibertiD· 3 shared Howard D. LipshitziD· 3 shared Hua LuoiD· 2 shared Sichun LiniD· 2 shared Stéphane AngersiD· 2 shared Timothy C.H. Low· 2 shared Aaron L. GoldmaniD· 1 shared Alireza Khademi· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersGenetics

Craig A. SmibertORCID

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3 papers

Recent·Most cited

GeneticsGeneticsPeer-reviewedNov 6, 2025

The ORB2 RNA-binding protein negatively regulates its target transcripts during the Drosophila maternal-to-zygotic transition via its functionally conserved Zinc binding 'ZZ' domain

Timothy C.H. Low, Hua Luo, Chalini Weerasooriya…·Howard D. Lipshitz

This study identifies ORB2 as a regulator of maternal mRNAs during the Drosophila MZT, showing its ZZ domain mediates repression through interactions with post-transcriptional regulators.

4 citations

Drosophilabulk RNA-seq

𝕏 PostBluesky

Developmental BiologyScience AdvancesPeer-reviewedApr 12, 2024

Smaug regulates germ plasm synthesis and primordial germ cell number in Drosophila embryos by repressing the oskar and bruno 1 mRNAs

Najeeb U. Siddiqui, Angelo Karaiskakis, Aaron L. Goldman…·Howard D. Lipshitz

The paper identifies Smaug's role in repressing osk and bru1 mRNAs to regulate germ plasm synthesis and PGC number in Drosophila embryos.

11 citations

Drosophilamultiome

𝕏 PostBluesky

GenomicsCell ReportsPeer-reviewedMar 1, 2020

The RNA-binding protein, Rasputin/G3BP, enhances the stability and translation of its target mRNAs

John D. Laver, Jimmy Ly, Jamie K. Winn…·Howard D. Lipshitz

This study identifies RIN/G3BP-bound mRNAs in Drosophila and shows they are short, stable, and highly translated, suggesting RIN stabilizes and enhances their translation.

56 citations

Drosophilabulk RNA-seq

𝕏 PostBluesky