Sichun Lin

This study identifies induced-proximity drugs that target β-catenin in colorectal cancer by recruiting Casein kinase I, leading to its degradation and inhibiting tumor growth.

This study identifies ORB2 as a regulator of maternal mRNAs during the Drosophila MZT, showing its ZZ domain mediates repression through interactions with post-transcriptional regulators.

The paper identifies Usp5 as a key interactor of Brat that facilitates pre-complex assembly for mRNA degradation during differentiation in Drosophila.

This study identifies SR-4835 as a CDK12 inhibitor that promotes cyclin K degradation via the proteasome by recruiting the CDK12-cyclin K complex to the CUL4-RBX1-DDB1 ubiquitin ligase complex.

The paper shows that precise degradation of post-transcriptional repressors during the Drosophila MZT is essential for orderly transition to zygotic gene control.

This study identifies RIN/G3BP-bound mRNAs in Drosophila and shows they are short, stable, and highly translated, suggesting RIN stabilizes and enhances their translation.