Author

Charles M. Soto

University of Florida

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:metabolomics· 3 Organism:mouse· 3 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Cameron J. ShedlockiD· 3 shared Craig W. Vander KooiiD· 3 shared Matthew S. GentryiD· 3 shared Ramon C. SuniD· 3 shared Terrymar Medina· 3 shared Alison M. Ryan· 2 shared Damon D. Kooser· 2 shared Derek B. AllisoniD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Cameron J. ShedlockORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Systemic hypoxia drives glycogen-fueled progression of lung adenocarcinoma

Harrison A. Clarke, Cameron J. Shedlock, Haley Peters, Tara R. Hawkinson, Damon D. Kooser, Olivia Janzen, Ariya Varma, Franca Bucco Paolasso, Charles M. Soto, Reece Larson, Alison M. Ryan, Terrymar Medina, Roberto A. Ribas, Christopher M. Calulot, Lei Wu, , Ramon C. Sun

This study shows systemic hypoxia promotes lung adenocarcinoma progression by mobilizing glycogen via GAA, supporting tumor growth through metabolic remodeling.

bioRxiv · Sep 3, 2026 · PreprintCancer Biology

A multi-organ spatial metabolomic atlas of exercising mice reveals neuronal Complex I as a convergent and sufficient axis for tau pathology reduction in PS19

Terrymar Medina, Sadi Quiñones, Zizhen Liu, Lei Wu, Borhane Ziani, Cameron J. Shedlock, Xin Ma, Alison Ryan, Reece Larson, Charles M. Soto, Vicenzo Barco-Caiaffa, Ann Titus, Kangjin Wong, Nidhi Rao, Sophia Florea, , Ramon C. Sun

This paper constructs a spatial metabolomic atlas of exercise in mice, identifies Complex I as a key target for reducing tau pathology, and shows that enhancing its activity mimics exercise's protective effects.

bioRxiv · Jun 22, 2026 · PreprintNeuroscience

Hyper-Glycosylation as a Central Metabolic Driver of Alzheimers Disease

Tara R. Hawkinson, Zizhen Liu, Roberto A. Ribas, Terrymar Medina, Rikke S. Nielsen, Harrison A. Clarke, Xin Ma, Angela C. Mueller, Adrielle F. Plasencia, Alexander L. Shear, Samantha T. Simpson, Charles M. Soto, Jessica Sudderth, Feng Cai, Alex R. Cantrell, , Ramon C. Sun

This study identifies hyper-glycosylation as a driver of Alzheimer's disease through metabolic analysis and interventions, showing its impact on cognitive decline and mortality.

bioRxiv · Apr 30, 2025 · PreprintNeuroscience