Reece Larson

This study shows folate deprivation impairs CD8+ T cell function by disrupting cell surface glycosylation, and increasing folate uptake enhances T cell anti-tumor activity.

This study shows systemic hypoxia promotes lung adenocarcinoma progression by mobilizing glycogen via GAA, supporting tumor growth through metabolic remodeling.

This paper constructs a spatial metabolomic atlas of exercise in mice, identifies Complex I as a key target for reducing tau pathology, and shows that enhancing its activity mimics exercise's protective effects.

The paper maps spatial metabolome coherence across mouse brain regions using MALDI imaging and optimal transport, showing preserved coherence in Alzheimer's model despite metabolic changes and demonstrating intervention effects.