Low RT-based Genome Editing Fidelity in Mouse Hepatocytes: Challenges and Solutions
Maike Thamsen Dunyak, Patrick Hanna, Angela Xinyi Nan, Jessica R. Von Stetina, Rejina Pokharel, Mollie O’Hara, Brett Estes, Kangni Zheng, Sonke Svenson, Jason L. Andresen, Wei Li, Mini Agrawal, Chase Hughes, Makayla Spicer, Vimal Choudhary, , Jonathan D. Finn
The paper identifies low fidelity in RT-based genome editing in non-dividing mouse hepatocytes and proposes solutions using neonatal mice and transgenic models.
bioRxiv · Oct 31, 2024 · PreprintBioengineering