Author

Patrick Hanna

ORCID 0000-0002-4998-2901Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:clustering· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1 Organism:non-human primate· 1

Frequent Co-Authors

Jonathan D. FinniD· 3 shared Maike Thamsen Dunyak· 3 shared Angela Xinyi Nan· 2 shared Brett EstesiD· 2 shared Jenny XieiD· 2 shared Jesse C. CochraneiD· 2 shared Jessica R. Von Stetina· 2 shared Martin MeagheriD· 2 shared

Activity by Year

2024-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBioengineering

Jonathan D. FinnORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Low RT-based Genome Editing Fidelity in Mouse Hepatocytes: Challenges and Solutions

Maike Thamsen Dunyak, Patrick Hanna, Angela Xinyi Nan, Jessica R. Von Stetina, Rejina Pokharel, Mollie O’Hara, Brett Estes, Kangni Zheng, Sonke Svenson, Jason L. Andresen, Wei Li, Mini Agrawal, Chase Hughes, Makayla Spicer, Vimal Choudhary, , Jonathan D. Finn

The paper identifies low fidelity in RT-based genome editing in non-dividing mouse hepatocytes and proposes solutions using neonatal mice and transgenic models.

bioRxiv · Oct 31, 2024 · PreprintBioengineering

Engineered Bxb1 variants improve integrase activity and fidelity

Joshua Rose, Hyaeyeong Kim, Jessica R. Von Stetina, Mahant Thangavelu, Hasahn L. Conway, Mollie S O'Hara, Patrick Hanna, Thomas C. Biondi, Maike Thamsen Dunyak, Jonathan D. Finn, Sandeep Kumar, Jesse C. Cochrane

The paper develops Bxb1 variants with improved integrase activity and fidelity, enhancing in vivo efficiency and reducing off-target effects.

bioRxiv · Oct 21, 2024 · PreprintBiochemistry

Curative levels of endogenous gene replacement achieved in non-human primate liver using programmable genomic integration

Jenny Xie, Maike Thamsen Dunyak, Patrick Hanna, Angela Xinyi Nan, Brett Estes, Jesse C. Cochrane, Shuai Wu, Jie Wang, Connor McGinnis, Qiang Wang, Rejina Pokharel, Dev Paudel, Jason Zhang, Dan Li, Parth H. Amin, , Jonathan D. Finn

This paper demonstrates programmable genomic integration in non-human primate liver, achieving curative levels of gene expression in over 50% of liver cells.

bioRxiv · Oct 12, 2024 · PreprintBioengineering