Highly specific σ2R/TMEM97 ligand alleviates neuropathic pain and inhibits the integrated stress response
Muhammad Saad Yousuf, James J. Sahn, Hongfen Yang, Eric T. David, Stephanie I. Shiers, Marisol Mancilla Moreno, Jonathan Iketem, Danielle M. Royer, Chelsea D. Garcia, Jennifer Zhang, Veronica M. Hong, Subhaan M. Mian, Ayesha Ahmad, Benedict James Kolber, Daniel J. Liebl, , Theodore John Price
This paper identifies FEM-1689 as a σ2R/TMEM97 ligand that alleviates neuropathic pain by inhibiting the integrated stress response in mice and human sensory neurons.
bioRxiv · Apr 11, 2023 · PreprintNeuroscience