Marisol Mancilla Moreno

E-Selectin Orchestrates IL-1B-Dependent Neuroinflammation via NLRP3 in Vincristine-Induced Neuropathy

This study identifies E-selectin as a key driver of IL-1B-dependent neuroinflammation in vincristine-induced neuropathy and suggests targeting E-selectin as a therapeutic strategy.

Satellite microglia-like cells in human dorsal root ganglia and changes with diabetic neuropathy

The paper identifies microglia-like cells in human dorsal root ganglia and shows their changes in diabetic neuropathy.

T-cell distribution in the dorsal root ganglion across species, sex, and age

The paper investigates T-cell distribution in the dorsal root ganglion across species, sex, and age, finding similar levels in humans, non-human primates, and pigs, but fewer in rats and absent in mice, with sex and age differences in humans.

Molecular architecture of human dermal sleeping nociceptors

The paper identifies OSMR and SST as molecular markers for human dermal sleeping nociceptors, providing new therapeutic targets for neuropathic pain.

A Reference Atlas of the Human Dorsal Root Ganglion

This paper constructs a human dorsal root ganglion reference atlas, identifying 22 neuronal subtypes and 10 non-neuronal cell types, and reveals functional differences between human and mouse DRG neurons.

Enabling wider access to human molecular neuroscience research in pain: A simple preservation method for human dorsal root ganglion neurons in Hibernate A media

This paper introduces a method to preserve human dorsal root ganglion neurons using Hibernate media, enabling easier access and transport for research.

Spatial transcriptomic profiling of human paravertebral sympathetic chain ganglia reveals diabetes-induced neuroplasticity

This paper uses spatial transcriptomics to analyze human sympathetic chain ganglia in diabetes, identifying neuronal and non-neuronal changes linked to autonomic dysfunction.

Single-cell characterization of the human C2 dorsal root ganglion recovered from C1-2 arthrodesis surgery: implications for neck pain

The paper characterizes human C2 dorsal root ganglion (DRG) using single-nucleus and spatial transcriptomics, identifying gene expression patterns linked to chronic neck pain.

Diroximel fumarate acts through Nrf2 to attenuate methylglyoxal-induced nociception in mice and decreases ISR activation in DRG neurons

This paper shows that diroximel fumarate (DRF) reduces MGO-induced pain hypersensitivity in mice by activating Nrf2 and decreasing ISR activation in DRG neurons.

Highly specific σ2R/TMEM97 ligand alleviates neuropathic pain and inhibits the integrated stress response

This paper identifies FEM-1689 as a σ2R/TMEM97 ligand that alleviates neuropathic pain by inhibiting the integrated stress response in mice and human sensory neurons.