The paper identifies a right-biased neuronal population in vagus nerves that expresses genes related to digestive signaling and may contribute to asymmetric reward processing.

Cell Reports · Nov 1, 2025Peer-reviewedNeuroscience

Highly specific σ2R/TMEM97 ligand alleviates neuropathic pain and inhibits the integrated stress response

Muhammad Saad Yousuf, James J. Sahn, Hongfen Yang, Eric T. David, Stephanie I. Shiers, Marisol Mancilla Moreno, Jonathan Iketem, Danielle M. Royer, Chelsea D. Garcia, Jennifer Zhang, Veronica M. Hong, Subhaan M. Mian, Ayesha Ahmad, Benedict James Kolber, Daniel J. Liebl, , Theodore John Price

This paper identifies FEM-1689 as a σ2R/TMEM97 ligand that alleviates neuropathic pain by inhibiting the integrated stress response in mice and human sensory neurons.

bioRxiv · Apr 11, 2023 · PreprintNeuroscience

A parabrachial-to-amygdala circuit that determines hemispheric lateralization of somatosensory processing

Heather N. Allen, Sarah Chaudhry, Veronica M. Hong, Lakeisha A. Lewter, Ghanshyam P. Sinha, Yarimar Carrasquillo, Bradley Kenneth Taylor, Benedict James Kolber

The paper identifies a parabrachial-to-amygdala circuit mediated by CGRP that drives hemispheric lateralization of visceral pain processing in mice.

bioRxiv · Sep 6, 2022Neuroscience