Activation of TrkB in Parvalbumin interneurons is required for the promotion of reversal learning in spatial and fear memory by antidepressants
Elias Jetsonen, Giuliano Didio, Frederike Winkel, Maria Llach Pou, Chloe Boj, Laura Kuczynski-Noyau, Vootele Võikar, Ramón Guirado, Tomi Taira, Sari E. Lauri, Eero Ċastrén, Juzoh Umemori
This study shows that TrkB activation in PV+ interneurons is essential for antidepressant-induced behavioral flexibility and synaptic plasticity in spatial and fear memory.
Neuropsychopharmacology · Mar 21, 2023Peer-reviewedNeuroscience