Frederike Winkel

This study shows that TrkB activation in PV+ interneurons is essential for antidepressant-induced behavioral flexibility and synaptic plasticity in spatial and fear memory.

This study identifies a direct binding of antidepressants to TRKB receptors, revealing a mechanism linking molecular interactions to antidepressant effects.

The paper uses optogenetics to activate TrkB receptors in the ventral hippocampus, enhancing plasticity and improving fear extinction in mice.

This study shows that chondroitinase and antidepressants promote plasticity in the adult visual cortex by enhancing TRKB signaling in parvalbumin neurons through inhibition of PTPσ.

The paper shows that optogenetic activation of TrkB receptors in PV interneurons increases cortical plasticity by altering neuronal excitability and gene expression.