Giuliano Didio

The BDNF/TrkB pathway in Somatostatin-expressing neurons suppresses cocaine-seeking behaviour

This study shows that TrkB-mediated plasticity in Somatostatin-expressing neurons is critical for the extinction of cocaine-seeking behavior and preventing relapse.

Activation of TrkB in Parvalbumin interneurons is required for the promotion of reversal learning in spatial and fear memory by antidepressants

This study shows that TrkB activation in PV+ interneurons is essential for antidepressant-induced behavioral flexibility and synaptic plasticity in spatial and fear memory.

Optical activation of TrkB neurotrophin receptor in mouse ventral hippocampus promotes plasticity and facilitates fear extinction

The paper uses optogenetics to activate TrkB receptors in the ventral hippocampus, enhancing plasticity and improving fear extinction in mice.

Optical TrkB activation in Parvalbumin interneurons regulates intrinsic states to orchestrate cortical plasticity

The paper shows that optogenetic activation of TrkB receptors in PV interneurons increases cortical plasticity by altering neuronal excitability and gene expression.