Elias Jetsonen

Chronic treatment with fluoxetine downregulates mitochondrial activity in parvalbumin interneurons of prefrontal cortex

This study shows chronic fluoxetine reduces mitochondrial activity in parvalbumin interneurons of the prefrontal cortex, potentially leading to disinhibition and enhanced synaptic plasticity.

Activation of TrkB in Parvalbumin interneurons is required for the promotion of reversal learning in spatial and fear memory by antidepressants

This study shows that TrkB activation in PV+ interneurons is essential for antidepressant-induced behavioral flexibility and synaptic plasticity in spatial and fear memory.

Optical TrkB activation in Parvalbumin interneurons regulates intrinsic states to orchestrate cortical plasticity

The paper shows that optogenetic activation of TrkB receptors in PV interneurons increases cortical plasticity by altering neuronal excitability and gene expression.