The gut microbiome shapes pharmacology and treatment outcomes for a key anti-inflammatory therapy
Vanya Sofia Villa Soto, Alexandra L. Degraeve, Chloe M. Heath, Diego A. Orellana, Erin R. Reilly, Mohana Mukherjee, Jacob G. Brockert, Darren S. Dumlao, Rebecca B. Blank, Noah Perlmutter, Steven Yu, Judith F. Ashouri, José U. Scher, Andrew D. Patterson, Peter James Turnbaugh, Renuka R. Nayak
This study shows that the gut microbiome affects methotrexate pharmacology in mice and contributes to interindividual variation in drug metabolism and treatment outcomes.
bioRxiv · Jun 26, 2025 · PreprintPharmacology & Toxicology