Author

Jacob G. Brockert

University of California, San Francisco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Darren S. DumlaoiD· 3 shared Bethany A. AndokoiD· 2 shared Hope D. WelhaveniD· 2 shared Kelsey H. CollinsiD· 2 shared Alexandra L. DegraeveiD· 1 shared Andreana G. Gomez· 1 shared Andrew D. PattersoniD· 1 shared Antonina M. AkkiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersPhysiology

Darren S. DumlaoORCID

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Author profile →

3 papers

Recent·Most cited

Adipose-driven complement-lipid reprogramming controls nociceptive vulnerability in obesity-associated osteoarthritis

Hope D. Welhaven, Joseph B. Lesnak, Kristin L. Lenz, Bethany A. Andoko, Arin K. Oestreich, Ashley N. Plumb, Katelyn E. Sadler, Luke E. Springer, Jacob G. Brockert, Darren Dumlao, Antonina M. Akk, Xiaobo Wu, Huimin Yan, Bo Zhang, Stephen P. Messier, , Kelsey H. Collins

The paper identifies an adipose-complement-lipid axis that systemically regulates sensory neuron sensitization, explaining pain-structure discordance in obesity-associated osteoarthritis.

bioRxiv · Mar 21, 2026 · PreprintPhysiology

Complement factor D (adipsin) mediates pressure-pain hypersensitivity post destabilization of medial meniscus injury

Priscilla M. Tjandra, Bethany A. Andoko, Jooyoung A. Kim, Jacob G. Brockert, Andreana G. Gomez, Sonya Sar, Megha R. Aepala, Tiffany T.K. Pham, Darren Dumlao, Hope D. Welhaven, Kelsey H. Collins

This study shows that absence of complement factor D increases pressure-pain hyperalgesia in mice after medial meniscus injury despite cartilage protection.

Arthritis Research & Therapy · Nov 26, 2025Peer-reviewedPhysiology

The gut microbiome shapes pharmacology and treatment outcomes for a key anti-inflammatory therapy

Vanya Sofia Villa Soto, Alexandra L. Degraeve, Chloe M. Heath, Diego A. Orellana, Erin R. Reilly, Mohana Mukherjee, Jacob G. Brockert, Darren S. Dumlao, Rebecca B. Blank, Noah Perlmutter, Steven Yu, Judith F. Ashouri, José U. Scher, Andrew D. Patterson, Peter James Turnbaugh, Renuka R. Nayak

This study shows that the gut microbiome affects methotrexate pharmacology in mice and contributes to interindividual variation in drug metabolism and treatment outcomes.

bioRxiv · Jun 26, 2025 · PreprintPharmacology & Toxicology