Katia Ancelin

Reassessing the "sexy" X hypothesis reveals distinct cellular and disease signatures of X-linked genes in male sexual differentiation and reproduction

The paper reassesses the 'sexy' X hypothesis by analyzing X-linked gene expression and associations with male-specific reproductive disorders, finding male-biased enrichment in testicular cell types and monogenic disorders.

Inversion of a topological domain leads to restricted changes in its gene expression and affects inter-domain communication

The paper inverts a topological domain and shows it causes limited gene expression changes but affects inter-domain communication, particularly in Xist expression.

EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells

This study identifies EZHIP as a novel cofactor of PRC2 that limits its activity in germ cells, leading to altered H3K27me2/3 deposition and impaired fertility in female mice.

Differential epigenetic landscapes and transcription factors explain X-linked gene behaviours during X-chromosome reactivation in the mouse inner cell mass

The paper investigates X-linked gene reactivation in mouse inner cell mass by analyzing epigenetic marks and transcription factors, finding differential reactivation speeds and mechanisms.