Topoisomerase IIb binding underlies frequently mutated elements in cancer genomes
Liis Uusküla-Reimand, Christian A. Lee, Robin Hyunseo Oh, Zoe P. Klein, Nina Adler, Sana Akhtar Alvi, Ellen R. Langille, Elisa Pasini, Kevin C.L. Cheng, Evgenija Serafimova, Diala Abd-Rabbo, Huayun Hou, Ricky Tsai, Mamatha Bhat, Daniel Schramek, , Jüri Reimand
The paper identifies TOP2B binding sites as mutational hotspots in cancer genomes, showing their role in structural variants and driver mutations in genes like TP53 and MYC.
Nature Communications · Nov 21, 2025Peer-reviewedCancer Biology