Repurposing passenger amplifications as Trojan horses identifies MPZL1 as a potent target for solid cancers
Sonia Jiménez Vázquez, Christos Patsis, Mara Mitstorfer, Melanie Grimm, Luise Butthof, Lena Wendler-Link, Lio Böse, Hendrik Wiethoff, Ilse Hofmann, Kai Breuhahn, Thomas Longerich, Matthias M. Gaida, Peter Schirmacher, Judith Feucht, Marco Breinig, Darjus Felix Tschaharganeh
The paper identifies MPZL1 as a therapeutic target in 1q-amplified solid cancers by repurposing passenger amplifications as Trojan horses for targeted therapy delivery.
bioRxiv · Sep 17, 2025 · PreprintCancer Biology