Enabling large-scale genome editing by reducing DNA nicking
Cory J. Smith, Oscar Castanon, Khaled Said, Verena Volf, Parastoo Khoshakhlagh, Amanda Hornick, Raphaël Ferreira, Chunting Wu, Marc Güell, Shilpa Garg, Alex H. M. Ng, Hannu Myllykallio, George McDonald Church
This paper develops dead-Cas9 base editors that enable large-scale genome editing in human cells by reducing DNA nicking, allowing editing of over 10,000 loci.
Nucleic Acids Research · Apr 1, 2020Peer-reviewedSynthetic Biology