Author

Khaled Said

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Synthetic Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Cory J. SmithiD· 3 shared George McDonald ChurchiD· 3 shared Amanda HornickiD· 2 shared Hannu MyllykallioiD· 2 shared Marc GüelliD· 2 shared Oscar CastanoniD· 2 shared Parastoo KhoshakhlaghiD· 2 shared Raphaël FerreiraiD· 2 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersSynthetic Biology

Cory J. SmithORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Enabling large-scale genome editing by reducing DNA nicking

Cory J. Smith, Oscar Castanon, Khaled Said, Verena Volf, Parastoo Khoshakhlagh, Amanda Hornick, Raphaël Ferreira, Chunting Wu, Marc Güell, Shilpa Garg, Alex H. M. Ng, Hannu Myllykallio, George McDonald Church

This paper develops dead-Cas9 base editors that enable large-scale genome editing in human cells by reducing DNA nicking, allowing editing of over 10,000 loci.

Nucleic Acids Research · Apr 1, 2020Peer-reviewedSynthetic Biology

CRISPR-mediated biocontainment

Oscar Castanon, Cory J. Smith, Parastoo Khoshakhlagh, Raphaël Ferreira, Marc Güell, Khaled Said, Ramazan Yildiz, Matthew Dysart, Stan Wang, David B. Thompson, Hannu Myllykallio, George McDonald Church

The paper develops CRISPR-based biocontainment circuits using transposable elements to induce cell death and create kill-switches for controlling cell lines.

bioRxiv · Feb 3, 2020 · PreprintSynthetic Biology

Rapid and scalable in vitro production of single-stranded DNA

Dionis Minev, Richard Guerra, Jocelyn Y. Kishi, Cory J. Smith, Elisha Krieg, Khaled Said, Amanda Hornick, Hiroshi M. Sasaki, Gabriel T. Filsinger, Brian J. Beliveau, Peng Yin, George McDonald Church, William M. Shih

This paper describes a method for producing high-purity single-stranded DNA for various applications.

bioRxiv · Feb 22, 2019 · PreprintMolecular Biology