Author

Alex H. M. Ng

Harvard UniversityORCID 0000-0001-5075-9750Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:CRISPR screen· 1 Assay:electrophysiology· 1 Research Focus:gene regulatory network inference· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

Amanda HornickiD· 1 shared Chunting Wu· 1 shared Cory J. SmithiD· 1 shared Daniel WendlandiD· 1 shared Elizaveta PodoliakiD· 1 shared George McDonald ChurchiD· 1 shared Hannu MyllykallioiD· 1 shared Helge GehringiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperSynthetic Biology

Amanda HornickORCID

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2 papers

Recent·Most cited

Empirical validation of ephaptic coupling in printed human neural circuits

Johannes Striebel, Rouhollah Habibey, Daniel Wendland, Helge Gehring, Elizaveta Podoliak, Julia Sophie Pawlick, Kritika Sharma, Alex H. M. Ng, Wolfram H. P. Pernice, Volker Busskamp

The paper validates ephaptic coupling in human neuronal circuits using a reproducible in vitro method, showing reduced action potential velocity and increased synchronization.

bioRxiv · May 21, 2025 · PreprintBioengineering

Enabling large-scale genome editing by reducing DNA nicking

Cory J. Smith, Oscar Castanon, Khaled Said, Verena Volf, Parastoo Khoshakhlagh, Amanda Hornick, Raphaël Ferreira, Chunting Wu, Marc Güell, Shilpa Garg, Alex H. M. Ng, Hannu Myllykallio, George McDonald Church

This paper develops dead-Cas9 base editors that enable large-scale genome editing in human cells by reducing DNA nicking, allowing editing of over 10,000 loci.

Nucleic Acids Research · Apr 1, 2020Peer-reviewedSynthetic Biology