Marc Güell

This study demonstrates that retron-mediated recombineering can be applied across multiple bacterial species, achieving high editing efficiencies in several phyla.

KMAP is a method for visualizing DNA sequences by projecting kmers into 2D space, showing it can detect patterns comparable to MEME and find biologically relevant interactions in ChIP-seq and gene editing data.

CRISPR-Analytics provides a tool and pipeline for accurate gene editing analysis and simulation, improving precision in experimental design and results interpretation.

This study enhances homology-directed repair (HDR) efficiency by using PRDM9-Cas9 fusion with CtIP, validated through reporter systems for small and longer edits.

INSERT-seq uses long-read sequencing to accurately detect DNA integration events, improving detection in repetitive regions.

The paper modifies pigs' genomes to create organs compatible with human transplantation by inactivating PERVs and engineering immune-related genes.

This paper develops dead-Cas9 base editors that enable large-scale genome editing in human cells by reducing DNA nicking, allowing editing of over 10,000 loci.

The paper develops CRISPR-based biocontainment circuits using transposable elements to induce cell death and create kill-switches for controlling cell lines.