Epigenetic Reactivation of Lineage Differentiation to Target Leukemia
Shandon M Amos, Chi-Chao Chen, Yichen Xiang, Keisuke Motoyama, Tania J González-Robles, Varun K. Narendra, Grace A. Johnson, Han‐Teo Lee, Yu-Jui Ho, Ipek Celikoyar, Ziyang Ye, Shenghao Guo, Claire Glickman, Natalie A. O’Hearn, Oindrila Sarkar, , Yadira M. Soto‐Feliciano
This study identifies TRIM28 as a critical regulator in acute leukemia, showing its depletion promotes neutrophil differentiation and reduces leukemic potential, with a small-molecule inhibitor developed to target it.
bioRxiv · Jul 10, 2026 · PreprintCancer Biology