Author

Shenghao Guo

Broad InstituteORCID 0000-0002-3032-2153Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Angela N. KoehleriD· 2 shared Yichen XiangiD· 2 shared Alexander HostetleriD· 1 shared Amit ChoudharyiD· 1 shared Arianna Arroyo-Ortega· 1 shared Becky S. LeiferiD· 1 shared Bocheng WuiD· 1 shared Chi-Chao CheniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

Angela N. KoehlerORCID

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2 papers

Recent·Most cited

Epigenetic Reactivation of Lineage Differentiation to Target Leukemia

Shandon M Amos, Chi-Chao Chen, Yichen Xiang, Keisuke Motoyama, Tania J González-Robles, Varun K. Narendra, Grace A. Johnson, Han‐Teo Lee, Yu-Jui Ho, Ipek Celikoyar, Ziyang Ye, Shenghao Guo, Claire Glickman, Natalie A. O’Hearn, Oindrila Sarkar, , Yadira M. Soto‐Feliciano

This study identifies TRIM28 as a critical regulator in acute leukemia, showing its depletion promotes neutrophil differentiation and reduces leukemic potential, with a small-molecule inhibitor developed to target it.

bioRxiv · Jul 10, 2026 · PreprintCancer Biology

Small molecule modulators of TOX protein re-invigorate T cell activity

Bocheng Wu, Heng Jui Chang, Prashant R. Singh, Alexander Hostetler, Yichen Xiang, Shenghao Guo, Fiona Yihan Wang, Julia J. Zhong, Becky S. Leifer, Richard P. Schiavoni, Nan Jiang, Amit Choudhary, Peter M.K. Westcott, Angela N. Koehler

This study identifies small molecule inhibitors of TOX protein that reverse T cell exhaustion and show cytotoxicity in T-ALL.

bioRxiv · Mar 3, 2025 · PreprintBiochemistry