Cas13d-mediated isoform-specific RNA knockdown with a unified computational and experimental toolbox
Megan D. Schertzer, Andrew Stirn, Keren Isaev, Laura Pereira, S H Park, Anjali Das, Aline Réal, Erin D. Jeffery, Claire Harbison, Hans‐Hermann Wessels, Gloria Sheynkman, Neville E. Sanjana, David A. Knowles
The paper develops a CRISPR/Cas13d-based method to specifically knockdown RNA isoforms and provides computational tools for experimental design and analysis.
Nature Communications · Jul 29, 2025Peer-reviewedGenomics