Guillermo Coronas‐Samano

cGAS inhibition delays TDP-43-driven ALS Pathogenesis

This study identifies cGAS as a key mediator of TDP-43 pathology in ALS and shows that its inhibition reduces RNA splicing defects and neurodegeneration.

Single-cell transcriptomic landscape of the neuroimmune compartment in amyotrophic lateral sclerosis brain and spinal cord

The paper identifies microglia subsets in ALS brain and spinal cord, finding an undifferentiated phenotype and enrichment of interferon response microglia in aggressive cases.

Behavioral deficits and exacerbated hemodynamics during lifespan of a mouse model of late onset Alzheimer's disease expressing humanized APOEϵ4 and Trem2*R47H

This study evaluates a mouse model of late-onset Alzheimer's disease, finding age-dependent behavioral deficits and hemodynamic changes in the olfactory bulb.