Daniel Giménez-Llorente

Integrative multi-omics reveals PARP14 as a key IFNγ-regulated mediator of metastatic progression in Ewing sarcoma.

This study identifies PARP14 as a key IFNγ-regulated mediator of metastatic progression in Ewing sarcoma through multi-omics analyses and functional experiments.

AT-hook-dependent DNA loop extrusion by STAG1 drives 3D genome folding

This study shows that STAG1's AT-hook motif enhances DNA loop extrusion by cohesin, driving 3D genome folding, while STAG2 lacks this feature.

A comprehensive genetic catalog of human double-strand break repair

This study presents a comprehensive catalog of human double-strand break repair genes using genome-wide knockout data, revealing novel mechanisms and factors involved in DSB repair.

miR-203 controls developmental timing and early fate restriction during preimplantation embryogenesis

This study identifies miR-203 as a regulator of developmental timing and cell fate restriction during the totipotency to pluripotency transition in mouse embryos using genetically engineered models and single-cell RNA sequencing.

Establishment of 3D chromatin structure after fertilization and the metabolic switch at the morula-to-blastocyst transition require CTCF

This study shows that CTCF is essential for establishing 3D chromatin structure and regulating metabolic and protein homeostasis during early mouse development, but these functions operate independently.

STAG2 cohesin is essential for heart morphogenesis

This study investigates the role of STAG2 cohesin in heart development by analyzing Stag2-ablated mice, finding essential roles in cardiac transcriptional programs and heart tube formation.

Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization

This study investigates the distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization in non-transformed human cells, showing SA1 stabilizes TAD boundaries while SA2 facilitates enhancer-promoter interactions.