Ana Losada

The paper shows that the CENP-A chaperone complex forms shell-like structures around centromeres in interphase, essential for centromere architecture and genome stability.

This study identifies PARP14 as a key IFNγ-regulated mediator of metastatic progression in Ewing sarcoma through multi-omics analyses and functional experiments.

This study shows that STAG1's AT-hook motif enhances DNA loop extrusion by cohesin, driving 3D genome folding, while STAG2 lacks this feature.

This study presents a comprehensive catalog of human double-strand break repair genes using genome-wide knockout data, revealing novel mechanisms and factors involved in DSB repair.

This study identifies miR-203 as a regulator of developmental timing and cell fate restriction during the totipotency to pluripotency transition in mouse embryos using genetically engineered models and single-cell RNA sequencing.

This study shows that CTCF is essential for establishing 3D chromatin structure and regulating metabolic and protein homeostasis during early mouse development, but these functions operate independently.

This study investigates the role of STAG2 cohesin in heart development by analyzing Stag2-ablated mice, finding essential roles in cardiac transcriptional programs and heart tube formation.

This study investigates the distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization in non-transformed human cells, showing SA1 stabilizes TAD boundaries while SA2 facilitates enhancer-promoter interactions.