Author

D. A. Levine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

I. Dolgalev· 2 shared A. Jagota· 1 shared A. Patel· 1 shared A. Rao· 1 shared A. Settle· 1 shared B. G. Neel· 1 shared B. R. King· 1 shared D. A. Heller· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCancer Biology

I. Dolgalev

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Author profile →

4 papers

Recent·Most cited

Drug-induced adaptation along a resistance continuum in cancer cells

G. S. Franca, M. Baron, M. Pour, B. R. King, A. Rao, S. Misirlioglu, D. Barkley, I. Dolgalev, K. Ho-Tang, G. Avital, F. Kuperwaser, A. Patel, D. A. Levine, T. Lionnet, I. Yanai

This study shows that gradual dose exposure and prolonged treatment drive ovarian cancer cell resistance to targeted therapy through a continuous adaptation process involving transcriptional, epigenetic, and genetic changes.

bioRxiv · Jun 21, 2022Cancer Biology

Machine-Perception Nanosensor Platform to Detect Cancer Biomarkers

Z. Yaari, Y. Yang, E. Apfelbaum, A. Settle, Q. Cullen, W. Cai, K. Long Roche, D. A. Levine, M. Fleisher, L. Ramanathan, M. Zheng, A. Jagota, D. A. Heller

This paper develops a machine-perception nanosensor platform using optical arrays and machine learning to detect cancer biomarkers in biofluids, achieving high F1-scores in uterine lavage samples.

bioRxiv · Apr 28, 2021 · PreprintBioengineering

Both Fallopian Tube and Ovarian Surface Epithelium Can Act as Cell-of-Origin for High Grade Serous Ovarian Carcinoma

B. G. Neel, S. Zhang, T. Zhang, I. Dolgalev, H. Ran, D. A. Levine

This paper shows that both fallopian tube and ovarian surface epithelium can originate high grade serous ovarian carcinoma, with distinct biological properties and therapeutic responses.

bioRxiv · Nov 29, 2018Cancer Biology

Immune-active microenvironment in small cell carcinoma of the ovary, hypercalcemic type: rationale for immune checkpoint blockade

P. Jelinic, J. Ricca, E. Van Oudenhove, N. Olvera, T. Merghoub, D. A. Levine, D. Zamarin

The paper reports immune responses in SCCOHT tumors, showing PD-L1 expression and T cell infiltration despite low mutation burden, suggesting potential for immune checkpoint blockade.

bioRxiv · Oct 4, 2017Cancer Biology